The Bishopric of Speyer (formerly known as Spires in English) is an ecclesiastical principality in what are today the German states of Rhineland-Palatinate and Baden-Württemberg.

It is secularized in 1803.

The prince-bishop resides in Speyer, a Free Imperial City, until the 14th century when he moves his residence to Uddenheim (Philippsburg) then Bruchsal in large part due to the tense relationship between successive prince-bishops and the civic authorities of the Free City, officially Protestant since the Reformation.

The prince-provostry of Wissemburg in Alsace is ruled by the prince-bishop of Speyer in a personal union relationship.