The Vilayet of Salonica is a first-level administrative division (vilayet) of the Ottoman Empire from 1867[4] to 1912. In the late nineteenth century it reportedly has an area of 12,950 square miles (33,500 km2).

The vilayet is bounded by the Principality (later Kingdom), of Bulgaria on the north; Eastern Rumelia on the northeast (after the Treaty of Berlin); Edirne Vilayet on the east; the Aegean Sea on the south; Monastir Vilayet and the independent sanjak of Serfije on the west (after 1881); the Kosovo Vilayet on the northwest.

It is dissolved after the Balkan Wars and divided among the Kingdom of Greece, Kingdom of Serbia and Tsardom of Bulgaria in 1913.