Hostilities broke out in 1486 between the Mamluks and the Ottoman Empire in a battle for control over western Asia, and the Ottomans capture Palestine in 1516.

Between the mid-sixteenth and seveneteenth centuries, a close-knit alliance of three local dynasties, the Ridwans of Gaza, the Turabays of al-Lajjun and the Farrukhs of Nablus, govern Palestine on behalf of the central Ottoman authorities.