The Viceroyalty of New Granada (Spanish: Virreinato de la Nueva Granada) is the name given on 27 May 1717, to a Spanish colonial jurisdiction in northern South America, corresponding mainly to modern Colombia, Ecuador, Panama, and Venezuela.

It is reestablished in 1739 after a short interruption, at which time the territory corresponding to Panama is incorporated.

In addition to these core areas, the territory of the Viceroyalty of New Granada includes Guyana, and parts of northwestern Brazil, northern Peru, Costa Rica and Nicaragua.

After several attempts to set up independent states in the 1810s, the kingdom and the viceroyalty cease to exist altogether in 1819 with the establishment of the Republic of Colombia.