The Despotate of the Morea or Despotate of Mystras is a province of the Byzantine Empire that exists between the mid-fouteenth and mid-fifteenh centuries.

Its territory varies in size during its one hundred years of existence but eventually grows to include almost all the southern Greek peninsula, the Peloponnesos, which is called Morea during the medieval period.

It is usually ruled by a close relative of the current Byzantine emperor, who is given the title of despotes (in this context it should not be confused with despotism).

Its capital is the fortified city of Mystras, near ancient Sparta, which becomes an important centerof Byzantine culture and power.