The Molossians are an ancient Greek tribe that has inhabited the central region of Epirus since the Mycenaean era.

On their northeast frontier they have the Chaonians and to their southern frontier the kingdom of the Thesprotians, to their north ware the Illyrians.

The Molossians are part of the League of Epirus until they side against Rome in the Third Macedonian War (171–168 BCE).

The result is disastrous, with the vengeful Romans enslaving 150,000 of its inhabitants and annexing the region into the Roman Empire.