The Mixtec (or Mixteca) are indigenous Mesoamerican peoples inhabiting the Mexican states of Oaxaca, Guerrero and Puebla in a region known as La Mixteca.

The Mixtecan languages form an important branch of the Otomanguean language family.The term Mixtec (Mixteco in Spanish) comes from the Nahuatl word Mixtecapan, or "place of the cloud-people."

The area in which Mixtec is spoken is known as the Mixteca.