Kizzuwatna is the name of an ancient Anatolian kingdom in the second millennium BCE.

It is situated in the highlands of southeastern Anatolia, near the Gulf of İskenderun in modern-day Turkey.

It encirclei the Taurus Mountains and the Ceyhan river.

The center of the kingdom is the city of Kummanni, situated in the highlands.

In a later era, the same region is known as Cilicia.