The Second Kingdom of Kakheti is a late medieval/early modern monarchy in eastern Georgia, centered at the province of Kakheti, with its capital first at Gremi and then at Telavi.

It emerges in the process of a tripartite division of the Kingdom of Georgia in 1465 and exists, with several brief intermissions, until 1762 when Kakheti and the neighboring Georgian kingdom of Kartli are merged through a dynastic succession under the Kakhetian branch of the Bagrationi dynasty.

Through most of its turbulent history, Kakheti is tributary to the Persians, whose efforts to keep the reluctant Georgian kingdom within its sphere of influence result in a series of military conflicts and deportations.