The Cusabo (also Corsaboy) are a group of historic Native American tribes who live along the coast of the Atlantic Ocean in what is now South Carolina, approximately between present-day Charleston and south to the Savannah River, at the time of European encounter.

English colonists often refer to them as one of the Settlement Indians of South Carolina, tribes who settle among the colonists.Five of the groups are recorded by the settlers as having spoken a common language, although one distinctly different from the major language families known nearby, such as Algonquian, Iroquoian, Muskogean and Siouan.

With the English settling on their land at Charleston beginning in the 17th century, the Cusabo develop a relationship of accommodation with the colony that persists through the early 18th century.

After the Yamasee War of 1715-17, surviving tribal members migrate to join the Creek or Catawba.