The Comtat Venaissin, often called the Comtat for short, is the former name of the region around the city of Avignon in what is now the Provence-Alpes-Côte d'Azur region of France.

It comprises roughly the area between the Rhône, the Durance and Mont Ventoux, with a small exclave located to the north around the town of Valréas bought by the pope John XXII.

The entire region is an enclave within the Kingdom of France.

The Comtat also borders (and mostly surrounds) the Principality of Orange.

Avignon itself is never part of the Comtat but constituted a separate comtat (county) in its own right, in effect forming an enclave within an enclave.

The region is still known informally as the Comtat Venaissin, although this no longer has any political meaning.