Banu Hanifa are an ancient Arab tribe inhabiting the area of al-Yamama in the central region of modern-day Saudi Arabia.

The tribe belons to the great Rabi'ah branch of North Arabian tribes, which also includes 'Anizzah, Abdul Qays, Bakr, and Taghlib.

Though counted by the classical Arab genealogists as a Christian branch of Bani Bakr, they led an independent existence prior to Islam.