Chrysaphius had become chamberlain (praepositus sacri cubiculi) in 443, which in practice makes him the chief minister of the weak Theodosius II.
Chroniclers record that he was all-powerful in the Palace (Theoph. 150; Priscus 227); the later Patria (II 182; Codinus 47) names him anachronistically as a parakoimomenos, after the all-powerful eunuch officials of the ninth and tenth centuries.
He schemes against the emperor's sister Pulcheria by exalting the influence of the empress Eudocia, and succeeds in arranging her withdrawal from the court for her policy to exile the Jews and destroy their synagogues.
She leaves for the seaport Hebdomon (Turkey) and becomes a nun to support Nestorianism in the Holy Land (Palestine).
Having accomplished this, Chrysaphius next intrigues against the empress, accusing her of adultery with Paulinus, a boyhood friend of the emperor.
She is then banished in 444.
Having removed both the emperor's wife and sister from the court, Chrysaphius is effectively ruler of the empire, and it is said that the emperor signed papers without reading them (Theophanes, A.M. 5942).