The Yamasee are the main concern within the colony's settlements, but British traders operating throughout the southeast had also found themselves to be caught up in the conflict.

Most have been killed.

Of about one hundred traders in the field when the war breaks out, ninety are killed in the first few weeks.

Attackers include warriors of the Creek (the Ochese, Tallapoosa, Abeika, and Alabama peoples), the Apalachee, Chickasaw, Choctaw, Catawba, Cherokee, and others.

During the first month of the war, South Carolina had hoped to receive assistance from the northern natives, such as the Catawba, but the first news from the north was that the Catawba and Cherokee had murdered British traders among them.

The Catawba and Cherokee had not attacked traders as quickly as did the southern natives, as both tribes were divided over what course to take.

Some Virginian traders are accused of goading the Catawba into making war on South Carolina.

Although the Catawba kill traders from South Carolina, they spare those from Virginia.

The Catawba by May 1715 send war parties against South Carolina settlers.

About four hundred Catawba warriors, joined by about seventy Cherokee, terrorize the northern parts of the colony.