Myles Coverdale, the Bible translator deposed from his bishopric of Exeter and suffering exile again after the succession of the Roman Catholic Queen Mary in 1553, removes to Denmark (where his brother-in-law is chaplain to the king).

The Ottomans conclude an unofficial armistice with Austria in 1553, recalling their main army for a new campaign in the protracted Turko-Persian War that had begun in 1526.

The Austrians unsuccessfully attempt a diplomatic annexation of the disputed Austrian Hungary.

Hürrem Sultan or Karima, born Alexandra Anastasia Lisowska, is the wife of Süleyman the Magnificent of the Ottoman Empire.

Known to Europeans informally as simply Roxelana, sixteenth-century sources are silent as to the maiden name, but much later traditions—for example, Ukrainian folk traditions first recorded in the nineteenth century—give it as "Anastasia" (diminutive: "Nastia"), and Polish traditions give it as "Aleksandra Lisowska".

She is known mainly as Hürrem Sultan or Hürrem "balsaq" Sultan; in European languages as Roxolena, transliterated as "Roksolana" Roxolana, Roxelane, Rossa, Ruziac; in Turkish as Hürrem (from Persian: Khurram, "the cheerful one"); and in Arabic as Karima ("the noble one").

"Roxelana""Roksolana" might be not a proper name but a nickname, referring to her Ukrainian heritage (cf. the common contemporary name Ruslana); "Roxolany" or "Roxelany" was one of the names of East Slavs, inhabitants of the present Ukraine, up to the fifteenth century.

Thus her name would literally mean "the Ruthenian one".

According to late-sixteenth-century and early-seventeenth-century sources, such as the Polish poet Samuel Twardowski, who researched the subject in Turkey, Hürrem was seemingly born to a father who was a Ukrainian ("Ruthenian" in the terminology of the day) Orthodox priest.

She was born in the town of Rohatyn, sixty-eight kilometers southeast of Lviv, a major city of Red Ruthenia (Chervona Rus'), at this time part of the Kingdom of Poland, today in western Ukraine.

Captured in the 1520s by Crimean Tatars during one of their frequent raids into this region, she had been taken as a slave, probably first to the Crimean city of Kaffa, a major center of the slave trade, then to Istanbul, where she had been selected for Süleyman's harem.

She had quickly come to the attention of her master, and attracted the jealousy of her rivals.

Süleyman's favorite, the concubine Mahidevran (also called "Gülbahar", Gül meaning Rose and Bahar meaning Spring), got into a fight with Hürrem one day and beat her badly.

Süleyman, upset by this, had banished Mahidevran to the provincial capital of Manisa, together with her son, the heir apparent, Prince Mustafa.

This exile is shown officially as the traditional training of the heir apparent, sancak beyligi.

Hürrem had thereafter become Süleyman's unrivaled favorite or haseki.

Many years later, Mustafa has now become a focus of disaffection in Anatolia.

The Sultan, heavily influenced by Roxelana, believes her false allegation that Mustafa is plotting to usurp the throne, and therefore has his eldest son beheaded in 1553.

Gulbahar (as the mother of the heir apparent) loses her state in the palace after the death of her son, and moves to Bursa.

Ottoman sultan Suleiman I begins his third and final campaign against the Persian Shah in 1553; he soon loses Erzurum.

Francis Xavier’s body, found to be undecayed after two months of burial, is later returned to Malacca and in December 1553 arrives to Goa (where it now rests).

Xavier gains posthumous renown as the Apostle of the Indies and of Japan.

Otomo Yoshishige, the daimyo of Bungo, has meanwhile requested that the Portuguese explorer Fernão Mendes Pinto return to Japan, and offers to convert to Christianity.

The letter arrives at the same time as Xavier's body is being displayed in Goa.

Pinto is to accompany the mission.

The Muslim forces had fallen back in confusion to Harar in 1543 when Imam Ahmad, who had led the Muslim conquest of the Ethiopian highlands, was killed.

Nur, the son of the dead leader’s sister, had married Ahmad Gragn’s firebrand widow, Bati del Wambara, and had undertaken to renew the fortunes of the Muslim city, which had been sacked in 1550.

Promoted to Emir around 1550-51, he has spend the past two years reorganizing his forces, and constructing the wall which still surrounds the city.

...Venice.

Paolo Caliari, called Il Veronese for his birthplace of Verona, where he trains as a painter, is influenced initially by Giulio Romano, whose mastery of illusionistic devices and allegorical themes the young Veronese tries to emulate in the elaborate frescoes (now largely destroyed) he executes in the early 1550s with Giovanni Battista Zelotti for the interior of the Villa Soranza.

He moves to Venice in 1553, by which time his passion for illusionistic and fanciful effects has merged with an admiration for the sumptuous colors employed by Titian.

The twenty-five-year-old Veronese immediately creates a sensation in Venice with the brilliant color and illusionistic impact of the ceiling panels he paints for the Sala dei Cosiglio dei Dieci (the Hall of the Council of Ten) and other chambers in the Doge's Palace.

Titian has from 1550 worked mainly for Philip II and as a portrait-painter.

For Philip, he paints a series of large mythological paintings known as the "poesie", mostly from Ovid, which are regarded as among his greatest works.

Thanks to the prudishness of Philip's successors, these are later mostly given as gifts and only two remain in the Prado.

Titian is producing religious works for Philip at the same time.

The "poesie" series began with Venus and Adonis, of which the original is in the Prado, but several versions exist, and Danaë with Nursemaid, both sent to Philip in 1553.

The artist's unmatched handling of color is exemplified by his Danaë with Nursemaid.

Although Michelangelo adjudges this piece deficient from the point of view of drawing, Titian and his studio produce several versions for other patrons.

...Ferrara, ...

...Mantua, ...

…Bologna, and …