Pires de Andrade's mission waits in Beijing to meet the Zhengde Emperor once more, but the emperor dies in 1521.

The new Grand Secretary, Yang Tinghe, rejects eunuch influence at court and rejects this new foreign embassy by the Portuguese once Malaccan ambassadors arrive in China damning the Portuguese for deposing their king; the Portuguese diplomatic mission languishes in a Chinese prison where they die.

Simão de Andrade, brother to ambassador Fernão Pires de Andrade, had also stirred Chinese speculation that the Portuguese were kidnapping Chinese children to cook and eat them; Simão had purchased children as slaves who will later be found by Portuguese authorities in Diu, India.