Operations in the Ottoman-Venetian War had been reduced mostly to isolated ravages and guerrilla attacks, until the Ottomans mounted a massive counteroffensive in 1470: this has Venice losing its main stronghold in the Aegean Sea, Negroponte.

The Venetians seek an alliance with the chief of the Ak Qoyunlu Turkmen confederation, with the Karamanids and with other European powers, but, receiving only limited support, can make only small-scale attacks at Antalya, Halicarnassus and Smirne.

However, the Ottomans conquer the Peloponnesus and launch an offensive in Venetian mainland, closing in on the important center of Udine.

The Turkmen, together with the Karamanian amir, are severely defeated at Terdguin, and the Republic is left alone.