Mustafa's brief reign, under the strong influence of his mother, witnesses continuous interference of the Janissaries in the administration and a revolt in Anatolia of Abaza Mehmed Pasa, who seeks to avenge Osman's death.

Mustafa is on September 10, 1623, deposed for a second time on the grounds of mental instability.

Eleven-year-old Murad IV, another son of Ahmed, succeeds on the deposition of his uncle.