Spanish convoys are making regular runs along the sea route from the New World to the Orient by the end of the sixteenth century.

Nanda Bayin's brothers, the viceroys of Toungoo, Prome, and Ava, revolt in 1599, and, after inviting the king of Arakan to join in the fray, besiege Pegu, take Nanda Bayin prisoner, and dismember the last remnants of Bayinnaung's empire.

Political and economic relations between Korea and Japan are suspended completely following the war.

Ieyasu, the most powerful of the five regents, forges alliances with various daimyo, especially those who had no love for Hideyoshi.

With the death in 1599 of Toshiie, the oldest and most respected of the regents, Ieyasu leads an army to Fushimi and takes over Osaka Castle, the residence of Hideyori.

This angers the three remaining regents and plans are made on all sides for war.

Opposition to Ieyasu centers upon Ishida Mitsunari, a powerful daimyo but not one of the regents.

Ishida plots Ieyasu's death and news of this plot reached some of Ieyasu's generals.

They attempt to kill Ishida but he flees and gains protection from Ieyasu himself.

Although it is unclear why Ieyasu would protect a powerful enemy from his own men, Ieyasu, a master strategist, may have concluded that he would be better off with Ishida leading the enemy army rather than one of the regents, who would have more legitimacy.

The royal Shaybanid patronage in Bukhara has fostered the rise of great, well-endowed seminaries and mosques, as wells as many major buildings and bridges.

The greatest of these dynasts, 'Abd Allah Khan II, who reigned from 1557 to 1598, has expanded Shaybanid rule in ...

...Samarkand, ...

...Tashkent, ...

...Fergana, and Balkh, hereby extending Uzbek hegemony eastward as far as Badakhstan and East Turkistan and westward to Khorasan and Khwarezm.

Russian trade with the Uzbek khanates has grown during the sixteenth century.

Boqimuhammad ascends the throne of Bukhara on the murder of the last Shaybanid ruler, Din Mohammed Khan, and establishes a new dynasty, the Janid, or Astrakhanids.

As a first order of business, he adjusts the foreign and domestic policies of his kingdom so that they will benefit the landlords and the merchants who have propelled him to his high position.

To implement these policies, he strengthens his military and introduces a new system of taxation.

The series of reforms thus launched places a great deal of undue pressure on the people of Bukhara, especially on the Kazakh and Karakalpak tribes to the north.

Boqimuhammad's rash policy decisions will In the long run destroy the good relationship that had persuaded the Bukharans to choose him as their ruler.

Most of Boqimuhammad's rule will therefore be spent putting down rebellions.

The Austrians ask for peace in 1599, but the Ottomans refuse.

István Bocskay, brought up at the court of the Báthorys, had won the confidence of Zsigmond, whom he had advised to form an alliance with the Habsburg ruler instead of with the Ottoman sultan.

When Báthory's successors deprive Bocskay of his estates in 1599, he flees to Vienna to seek protection and redress.

He is alienated, however, by the emperor’s attempts to deprive royal Hungary of its constitution and the Hungarian Protestants of their religious liberties.

Andreas Báthory, a Roman Catholic, has become increasingly active in the Counter-Reformation, to the dismay of the leading Transylvanian nationalists, most of whom are Protestant.

He decides in 1599, to take holy orders; he separates from his wife, the archduchess Christina of Austria, and gives up his throne, offering it to Emperor Rudolf (who is also king of Hungary) in exchange for the Silesian duchy of Oppeln (Opole).