Leonardo, working in Milan from 1482 until 1499, is commissioned to paint the Virgin of the Rocks for the Confraternity of the Immaculate Conception and, in 1495, The Last Supper for the monastery of Santa Maria delle Grazie.

Between 1493 and 1495 Leonardo has listed a woman called Caterina among his dependents in his taxation documents.

At her death in 1495, the list of funeral expenditures suggests that she was his mother.