Edward Jenner tests his hypothesis on May …

Years: 1796 - 1796
May

Edward Jenner tests his hypothesis on May 14, 1796, by inoculating James Phipps, a boy eight years old (the son of Jenner's gardener), with pus scraped from the cowpox blisters on the hands of Sarah Nelmes, a milkmaid who had caught cowpox (from a cow called Blossom, whose hide now hangs on the wall of the St. George's medical school library, now in Tooting).

Phipps is the seventeenth case described in Jenner's first paper on vaccination.

Jenner inoculates Phipps in both arms that day, subsequently producing in Phipps a fever and some uneasiness but no full-blown infection.

Later, he injects Phipps with variolous material, the routine method of immunization at this time.

No disease follows.

The boy is later challenged with variolous material and again shows no sign of infection.

Ronald Hopkins has written, "Jenner's unique contribution was not that he inoculated a few persons with cowpox, but that he then proved [by subsequent challenges] that they were immune to smallpox.

Moreover, he demonstrated that the protective cowpox pus could be effectively inoculated from person to person, not just directly from cattle. (Hopkins, Donald R. (2002). The greatest killer: smallpox in history, with a new introduction. Chicago: University of Chicago Press. p. 80).

In addition, Jenner successfully tests his hypothesis on twenty-three additional subjects.

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