The Spanish colonists, heading southward, likely by …

Years: 1526 - 1526

The Spanish colonists, heading southward, likely by both land and sea, reunite and on October 8, 1526 establish the short-lived colony of San Miguel de Gualdape, the first European settlement in the North American continent, probably at or near present-day Georgia's Sapelo Sound.

Ayllón dies on October 18 during a fever epidemic in the colony, purportedly in the arms of a Dominican friar.

His new colony uses the labor of enslaved Africans—perhaps the first instance within the present territory of the United States.

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