Ghirlandaio is among the Florentine painters who had received van der Goes’s “Portinari Altarpiece” with great enthusiasm.

He borrows van der Goes's shepherds for his Adoration of the Shepherds, painted in 1485 for the Church of Santa Trinita in Florence.

Sandro Botticelli and his Florentine workshop have from 1482 produced numerous paintings of all types: mythologies, portraits, small-scale devotional pictures, and altarpieces, such as the “St. Barnabas Altarpiece” created in about 1488.

Botticelli paints his celebrated (and widely imitated) “Madonna of the Magnificat” in around 1483-85.

He paints in about 1485, hone of his most famous works, the large-scale Birth of Venus, another of the mythological paintings in which he celebrates in Neoplatonic symbolism the beneficence and wisdom of Medici rule.