Some sources (Philostorgius) claim Gallus' generals won a campaign against the Sassanids.
Others, basing their views on an almost-peaceful situation between Sassanids and Romans, dismiss this claim.
In 354, Gallus sends the comes Orientis, Nebridius, against the Isaurians, who had been raiding the city of Seleucia on the Tigris.
As a consequence of the need to gather food for the troops of a Persian campaign or because of drought, the grain supply in Antioch has decreased.
In order to counter the higher price of grain, Gallus forces the passage of some laws regardless of the opinion of the Senate, thus alienating the support of the senatorial class of Antioch.
Ammianus Marcellinus, a philo-senatorial writer, tells how the anger of the people of Antioch for the famine was diverted by Gallus towards the consularis Syriae Theophilus, who was killed by the mob.
Ammianus reports also that Gallus and Constantina started several trials for magic against wealthy people, ending in the execution of innocents and in the confiscation of their wealth.
The same source claims that Gallus walked anonymously in Antioch by night, asking passersby for their opinion on their caesar, while Julian records the great amount of time spent by Gallus at the Hippodrome, probably to obtain popular support.
Doubting his cousin's loyalty, Constantius reduces the troops under Gallus, and sends the Praetorian Prefect Domitianus to Antioch to urge Gallus to go to Italy.
Different sources tell different stories, but all agree that Gallus arrested Domitianus and the quaestor Montius who had come to his aid, and that the two officers were killed.
The arrest of Montius leads to the discovery of what seems to be a plot to elevate an usurper against Gallus.
The conspirators have the support of two tribuni fabricarum (officers of the weapons factories) who had promised the weapons for an uprising (Ammianus Marcellinus, 14.7.18), and probably of the troops in Mesopotamia, as well as of the rector of the province of Phoenice.
All of those involved in the plot are sentenced to death.
Constantius, during a campaign against the Alamanni, had been informed of the trials in Antioch held by Gallus.
Having signed a peace with the Germanic tribe, Constantius decides to settle the matter with his cousin.
First he summons Ursicinus to the West, whom he suspects to have been inciting Gallus in order to create the occasion for a revolt and the usurpation of his own son.
Next, Constantius summons Gallus and Constantina to Milan.
Constantina leaves first, in order to gain some of her brother's trust, but dies at Caeni Gallicani in Bithynia.
Gallus, his bonds to Constantius thus further weakened, stays in Antioch.
Constantius tries to lure Gallus, sending the tribunus scutariorum Scudilo to tell Gallus that Constantius wants to raise him to Augustus.
Gallus desiring to finally obtain the rank of Augustus, takes Constantius's bait and leaves Antioch to meet him.