Donato Bramante, just before leaving for Rome in 1499, completes his second great work in Milan, the enlargement of the church of Santa Maria della Grazie, making of the interior a vast monumental version of Filippo Brunelleschi's old sacristy in the church of San Lorenzo in Florence.

The design of the apse of the church has been attributed to Bramante; however, while it was built while he was in the service of the Duchy, there is scant documentary evidence linking him to this church.

His name is inscribed in a piece of marble in the church vaults delivered in 1494.

Some document, though, mention the name Amadeo, likely Giovanni Antonio Amadeo.

Similarities to his work at Santa Maria alla Fontana make this attribution more likely.

However, there is no real evidence of the fact other than that Bramante lived in Milan at this time, and he continued the Gothic style from the first part, but mixed with Romanesque influence.