Della Quercia completes the decoration of the main portal of San Petroni for the Cathedral of Bologna, creating, in the ten marble relief panels that flank the doorway, depicting stories from the Book of Genesis, the most impressive sculpture of the age.

He balances a somewhat conservative treatment of space with his powerful conception of the human body, eloquently expressed by the weighty, monumental figures and muscular, idealized nudes.

He dies on October 20, 1438.