David Reubeni, joining once more with Solomon Molcho, travels with streaming banner to Bologna and Ratisbon (Regensburg) to meet the Emperor Charles V. Reubeni offers Charles V the alliance of Jews of the East against the Ottoman Empire.

In Ratisbon, Reubeni and Molcho meet Josel of Rosheim, who warns them against arousing the suspicions of the emperor.

Josel is worried about raising issues of the Jews in the empire.

When Reubeni and Molcho persist, officials put them in chains and take them to the emperor in Mantua, where both Molcho and Reubeni will be examined by inquisitors.

The former will be condemned to burning at the stake in 1530.

Reubeni will be taken to Spain and assigned to the Inquisition at Llerena.

As late as 1535 he will still be confined in a prison there.

Nothing more will be heard of him.

He will probably die here, as Herculano reported that "a Jew who came from India (sic) to Portugal" was burned at an auto da fé at Évora in 1541.

Another source said Reubeni died in Llerena, Spain, after 1535.