Constantinople makes several attempts to retake Alexandria.

None of these are successful for a sustained period of time, but imperial forces in 645 are able to briefly regain control of the city, when Uthman dismisses Amr as military governor of Alexandria.

Constans, taking advantage of the power vacuum, dispatches a fleet to besiege the city, successfully at first, as Alexandria revolts from Arab rule at the appearance of three hundred ships of the imperial fleet, whose forces recapture the city.

Arab chroniclers tell of a massive fleet and army sent by Constantinople with the goal of retaking Alexandria.

The imperial forces are led by a lower ranking imperial official named Manuel.

After entering the city without facing much resistance, the imperial forces are able to regain control of both Alexandria and the surrounding Egyptian countryside.