Constantine lavishly endows Rome's great church of St. Peter, begun in the later 320s, with plate and property.

Churches at Trier, Aquileia, Cirta in Numidia, Nicomedia, Antioch, Gaza, Alexandria, and elsewhere owe their development, directly or indirectly, to Constantine's interest.

Rome has long been unsuited to the strategic needs of the empire: it is now to be left in splendid isolation, as an enormously wealthy and prestigious city—still the emotional focus of the empire—but of limited political importance.

Italy's administrative autonomy is lost shortly after Constantine’s transfer of the imperial capital from Rome to Constantinople, when two dioceses are joined with that of Africa to form a single prefecture.