The other militia sent by Buenos Aires is commanded by Manuel Belgrano and had made its way up the Paraná River towards the Intendency of Paraguay, whose only city is Asunción.

A first battle was fought on December 19, 1810, at Campichuelo, where the Patriots claim victory.

However, they had been completely overwhelmed at the subsequent battles of Paraguarí on January 19 and Tacuarí on March 9.

Thus, this campaign ends in failure as well from a military point of view; however, just two months later, Paraguay, inspired by the Argentine example, will break its links with the Spanish crown by declaring itself an independent nation.