Calvin, now virtual ruler of Geneva, establishes the Collège de Genève in 1559, extending the circle of his influence.

As the Collège Calvin, it is today is the oldest public secondary school in Geneva.

The last edition of his Institutes of the Christian Religion, published in this year, has grown in twenty-three years from six brief sections to seventy-nine full chapters.

Calvin clearly and emphatically presents his vision of God in his majesty, of Christ as prophet, priest, and king, of the Holy Spirit as the bestower of faith, of the Bible as the supreme authority, and of the church as God’s holy people.

Calvin deduces his fatalistic doctrine of predestination from his belief in human sinfulness and God's sovereign mercy in Christ.