Anullinus enters Syria eventually and the final battle takes place in May 194, near Issus, the place where Alexander the Great defeated the Persian King Darius III in 332 BCE.

Severus takes advantage of the control he had on the lives of the children of the provincial governors, who are left at Rome, as well as the rivalries of the cities in the region, thus encouraging governors to change sides, one legion to desert to him and some cities to revolt.

Severan troops attack first while Niger's forces are hurling missiles against them.

At the same time, the Severan cavalry attacks from the rear.

The fight is hard but in the end Severus wins decisively and Niger flees back to Antioch.

A sudden thunderstorm plays some role in lowering the morale of Niger's troops, who are directly facing it, because they attribute it to divine intervention.

A triumphal arch is set on site, commemorating the victory of Severus.

This concludes hostilities on the field between the two rivals for control of the East (Niger is captured and killed, a few days later).