One settler, Joshua Baker, operates an inn or tavern of sorts, selling grog to both whites and natives, at the mouth of Yellow Creek, small tributary of the Ohio River located on the western (Ohio) bank about forty miles above Wheeling, Virginia (now West Virginia) and about forty miles (sixty-four kilometers) west northwest of Fort Pitt (now Pittsburgh).

Many of the inhabitants of the area have already evacuated, due to the warning sent by John Connolly.

Baker is likewise preparing to leave when an Indian woman tells him that natives are preparing to murder him and his family.

Baker gets out word that he needs help.

Daniel Greathouse, leading a group of twenty-one men, comes to his aid.

The group reaches Baker's on April 30, 1774, and are concealed by Baker in a back room.

Seven natives come across the river to Baker's place, including the brother of Logan, a prominent warrior of the Mingo tribe, and two women and a child, also related to Logan.

The natives begin to drink.

When Logan's brother puts on a hat and coat belonging to one of the settlers, the settler shoots and kills him.

Greathouse's men who had been concealed in the back room rush out and kill all the remaining natives except for the child.

As they leave the tavern, they see two canoes of native men painted and armed for war, coming across the river.

Greathouse's group fire on them, killing most of the occupants of one of the canoes; the others turn back.

It is said that Greathouse took the scalps of his native foes and dangled them from his belt, scalping being a declaration of war among the natives.

This massacre, following a series of incidents, is the final break in relations between the white settlers and the natives and is considered the immediate cause of Lord Dunmore's War of 1774, in which the natives will wreak terrible vengeance on the white settlers.