The severe devastation to the European population …

Years: 268 - 279

The severe devastation to the European population from the Antonine Plague (166–180) and the Plague of Cyprian (251–270) may indicate that the people had no previous exposure or immunity to the plague's cause.

Historian William Hardy McNeill will assert that both the earlier Antonine Plague (166–180) and the Plague of Cyprian (251–270) represent the first transfers from animal hosts to humanity of two different diseases, one of smallpox and one of measles, although not necessarily in that order.

D. Ch. Stathakopoulos will assert that both outbreaks were of smallpox.

According to historian Kyle Harper, the symptoms attributed by ancient sources to the Plague of Cyprian better match a viral disease causing a hemorrhagic fever, such as Ebola, rather than smallpox. (Conversely, Harper believes that the Antonine Plague was caused by smallpox.)

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